XIAP Antibody

XIAP Antibody is a Rabbit Polyclonal antibody against XIAP. This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.

Target	XIAP
Reactivity	Human, Mouse, Rat
Origin	Human
Host	Rabbit
Clonality	Polyclonal
Tested Applications	WB
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	A synthetic peptide of human XIAP.
Purification	Affinity purified.
Form	Liquid
Isotype	IgG
Conjugation	Unconjugated
Storage	Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight	Calculated MW: 56 kDa Observed MW: 54 kDa
Swiss Prot	P98170
GeneID	331
Gene Symbol	XIAP
Concentration	> 1 mg/ml
Buffer	PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.