CD45 Antibody (DyLight 634)

The CD45 molecule is also known as the Leukocyte Common Antigen (LCA) or T200 antigen, and is comprised of different glycoproteins ranging from 180-240 kDa. Expression of CD45 is found on all hemopoietic cells, e.g. granulocytes, monocytes, macrophages and lymphocytes, except mature erythroid cells. Detection of the different isoforms can distinguish, for example, between naive T cells and memory T cells, which is of interest in patients with immunodeficiency and autoimmune diseases.

Target	CD45
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Tested Applications	FCM
Recommended dilutions	FCM: 20 μl/1 million cells. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Human Peripheral Blood Leucocytes.
Purification	Affinity Chromatography
Form	Liquid
Isotype	IgG1
Conjugation	DyLight 634
Specificity	he 180, 195, 205, 220, kD MW components of the leucocyte common antigen complex to be found on lymphocytes, monocytes, granulocytes, thymocytes and malignant T and B cells. No reactivity has been observed with primary or metastatic carcinoma cells. Plasma cells or myeloma cells may have weak expression or be negative for this antigen
Storage	Store in the dark at 2-8 °C.
Molecular Weight	180-220 kDa
Swiss Prot	P08575
GeneID	5788
Enzyme Commission Number	EC 3.1.3.4
Buffer	The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium Azide
Availability	Shipped within 2-3 weeks.
Note	This product is for research use only.