THY1 Antibody

THY1 Antibody is a Rabbit Polyclonal antibody against THY1. THY1 is a GPI-anchored, developmentally regulated protein involved in various signaling cascades that mediate neurite outgrowth, T cell activation, tumor suppression, apoptosis, and fibrosisIt is highly expressed on the surface of ***** neurons and is thought to play a role in modulating adhesive and migRatory events, such as neurite extensionDecreased THY1 expression is associated with the development of epithelial ovarian cancer, revealing its role as a putative tumor suppressor gene of human ovarian cancerTHY1 knockout mice have impaired cutaneous immune responses and abnormal retinal developmentTHY1 is epigenetically regulated, or deregulated in some disease states, such as pulmonary fibrosisThe potentially reversible hypermethylation of the THY1 promoter offers the possibility of novel therapeutic options in this disease.

Target	THY1
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Tested Applications	WB, IHC
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Purification	Affinity purified.
Isotype	IgG
Conjugation	Unconjugated
Storage	Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Swiss Prot	P04216
Buffer	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.