Quidel Polyclonal Antiserum to Vitronectin Protein

产品介绍
品名	Quidel Polyclonal Antiserum to Vitronectin Protein
货号	A319
规格	1.0 mL
形式	Whole Antiserum
防腐剂	≤ 0.1% Sodium Azide
物种交叉反应	Species cross reactivity not tested
储存	2°C to 8°C  (≤ 30 days) For long-term storage (> 30 days), aliquot and store at ≤ –20°C. Avoid repeated freeze-thaw.
使用说明	For Research Use Only. Not for use in diagnostic procedures
产品描述	Highly purified human Victronectin was isolated and used to immunize rabbits. The Anti-Human Vitronectin polyclonal antisera was tested by immunodiffusion methods and determined to be monospecific for the Vitronectin protein
背景	In contrast to membrane-formed C5b-9 complexes, C5b-9 complexes formed in the fluid phase contain an additional protein, the S protein. Subsequently, it was found that isolated S protein inhibited C5b-9 attachment. S protein functions like a “membrane analogue” in that it binds to the binding site generated on assembly of C5b-9 and is required for insertion of the complex into the membrane. As a result, SC5b-7, SC5b-8 or SC5b-9 complexes are formed which have lost their membrane-binding capacity. When the S protein was cloned and sequenced, it was found to be identical to Vitronectin. Within the complement cascade, Vitronectin not only inhibits attachment of C5b-9 to target cells, but also prevents C9 polymerization. The biological function of Vitronectin is to minimize complement-mediated attack of cells near an ongoing complement attack
应用	Applications of the Anti-Human Vitronectin antisera have been evaluated, and include immunodiffusion, Western Blot and ELISA