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Anti-Histone H3.3 G34R Rabbit Monoclonal Antibody, Clone RM240; Histone H3.3 G34R Mutant

  • 产品名称：Anti-Histone H3.3 G34R Rabbit Monoclonal Antibody, Clone RM240; Histone H3.3 G34R Mutant
  • 产品型号：31-1120-00
  • 产品厂商：RevMAb
  • 产品文档：
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简单介绍

Anti-Histone H3.3 G34R Rabbit Monoclonal Antibody, Clone RM240; Histone H3.3 G34R Mutant

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Product Details
Product Name Anti-Histone H3.3 G34R Rabbit Monoclonal Antibody [RM240]
Product Description Rabbit monoclonal to Histone H3.3 G34R; Histone H3.3 G34R Mutant
Catalog No. 31-1120-00
Clone Name RM240
Product Data Sheet Anti-Histone H3.3 G34R Mutant Rabbit Monoclonal Antibody Data Sheet RM240
Specificity RM240 reacts to the Histone H3.3 G34R mutant. No cross reactivity with wild type Histone H3.3 .
Immunogen A peptide corresponding to Histone H3.3 G34R mutant
Application Western Blot
ELISA
Immunohistochemistry
Immunocytochemistry
Chromatin IP
Species Reactivity All
Conjugate None
Intended Use Research Use Only
.
Properties
Form Liquid
Storage Instructions Store at -20.0°C
Stability Stable for 1 Year at -20.0°C from date of receipt
Storage Buffer 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Volume/Size 50 ug
Concentration 1.0 mg/mL
Purity Protein A affinity purified from an animal origin–free culture supernatant
Clone Type Monoclonal
Isotype Rabbit IgG
Usage Western Blot: 0.5 ug/mL – 2 ug/mL;
ELISA: 0.5 ug/mL - 2 ug/mL;
Immunohistochemistry (IHC): 0.5 – 5 ug/mL;
Immunocytochemistry (ICC): 0.5 – 5 ug/mL.
References for Histone H3.3 G34R Mutant antibody [RM240] Pathania et al. H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor
Cells to Induce Invasive High-Grade Gliomas Cancer Cell (2017)10.1016/j.ccell.2017.09.014. WB; Human. Read more (PubMed: 29107533)

Yamamoto H.et al. Diagnostic utility of histone H3.3G34 W, G34R, and G34 V mutant-specific antibodies for giant cell tumors of bone. Human Pathology (2017)10.1016/j.humpath.2017.11.020 IHC; Human. Read more (PubMed: 29241742)
.
Product Images
Western

Western Blot analysis of cell lysates prepared from
 293T, transfected with a DNA construct encoding
G34R mutant or wild type proteins of Histone H3.3,
using anti-Histone H3.3 G34R clone RM240.

Immunohistochemical

Immunohistochemical staining of formalin fixed and
 paraffin embedded 293T cells transfected with a DNA
construct encoding Histone H3.3 G34R mutant or wild
 type, stained with anti-Histone H3.3 G34R clone RM240.

IHC

IHC of clinically validated FFPE Glioblastoma tumor
tissues with H3.3 G34R expression, using anti-histone
H3.3 G34R rabbit monoclonal antibody, Clone RM240.
Clinically validated to be Positive for H3.3 G34R Mutation.

Image courtesy of Dr. Sebastian Brandner, UCL
 Institute of Neurology, London, United Kingdom

IHC

IHC of clinically validated FFPE Glioblastoma tumor
tissues, using anti-histone H3.3 G34R rabbit
monoclonal antibody, Clone RM240. Clinically validated
 to be Negative for H3.3 G34R Mutation.

Image courtesy of Dr. Sebastian Brandner, UCL
 Institute of Neurology, London, United Kingdom

ICC staining of primary human cell lines expressing
 WT and H3.3 G34R Mutation.

Image courtesy of Dr. Nada Jabado, McGill University,
Montreal, Quebec, Canada.


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